THE APPLICATION OF THE TOE FRAMEWORK TO THE ADOPTION OF CRM BY SMES IN KWAZULU NATAL


Radiobiological evaluation of the influence of dwell time modulation restriction in HIPO optimized HDR prostate brachytherapy implants

Purpose: One of the issues that a planner is often facing in HDR brachytherapy is the selective existence of high dose volumes around some few dominating dwell positions.If there is no information available about its necessity (e.g.location of a GTV), then it is reasonable to investigate whether this can be avoided.This effect can be eliminated by

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Targeting active RAS with molecular glue

Activating mutations in RAS genes, notably KRASG12C, are pervasive in numerous cancers, presenting formidable challenges to therapy due to their elusive druggability.The landmark discovery of KRASG12C allosteric inhibitors marked a transformative milestone in cancer treatment, Borage Oil resulting in the approval of sotorasib and adagrasib.However,

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